3 Best CBD Melatonin Capsules for Sleep: Reviews & Guide (April 2022)

By | last updated March 29, 2023

Medically reviewed by
Saira Zulfiqar, PharmD

Evidence Based 13

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Many people take melatonin-infused CBD products to relieve insomnia and improve their overall sleep quality.

But with such a wide variety of available products, it’s not always easy to make a choice. Many products contain less CBD than advertised, while others are simply too weak to produce the desired effect.

To make your search easier, we compared dozens of products based on third-party lab test results, hemp quality, potency, formula, customer reviews, price, and other criteria. Read on for our reviews of the best CBD melatonin capsules for sleep.


The overall best CBD melatonin capsules are offered by Lazarus Naturals. I tested them for a few weeks and they helped me fall and stay asleep easier. Their multi-ingredient sleep formula is also quite impressive.

  1. Best Overall: Lazarus Naturals sleep + melatonin capsules | full review
  2. Best THC-Free: cbdMD PM softgels | full review
  3. Best Reviews: Green Roads sleep CBD capsules | full review

CBD Terminology

  • Hemp: cannabis variety with high CBD and low THC levels (no more than 0.3%).
  • Terpenes: aromatic plant compounds with a wide variety of beneficial properties (1).
  • Minor cannabinoids: CBN, CBG, CBC, and other beneficial cannabinoids found in smaller amounts in hemp. They may work in synergy with CBD.
  • Full-spectrum: whole-plant hemp extract containing multiple cannabinoids, terpenes, and flavonoids. This form of CBD may be about 4 times more potent than pure CBD (2).
  • Broad-spectrum: whole-plant hemp extract similar to full-spectrum CBD, but with THC removed (may contain trace amounts).
  • CBD isolate: pure CBD with all other hemp compounds removed.

Lazarus Naturals Sleep+Melatonin Capsules (Best Overall)

lazarus naturals sleep + melatonin capsules


Potency50 mg/ml
Capsule Count10-40
Total cannabinoids500-2000 mg
Cost per mg $0.03-0.04
Third-Party TestsView report


  • Exceptionally low price
  • Full-spectrum CBD
  • Multi-ingredient sleep formula
  • USDA organic hemp


  • None

Out of all the melatonin CBD capsules we reviewed, Lazarus Naturals’ sleep+melatonin capsules are the clear winner.

Their specialized sleep formula contains 30 mg full-spectrum CBD, 10 mg CBG, and 10 mg cannabinol (CBN), a minor cannabinoid touted to have sleep-promoting effects. There’s also 5 mg melatonin, plus the popular sleep herbs passionflower and lemon balm.

More importantly, these capsules cost only 2.5 to 4 cents per mg of cannabinoids, which is cheap.

The employee-owned Lazarus Naturals is one of the most popular CBD brands on the market. It controls every step of the production process, beginning with growing its own USDA-certified organic hemp in Central Oregon.

My experience: I took two capsules about an hour before bed. By the time I was under the sheets, I was feeling more relaxed than normal and fell asleep easier.

CbdMD CBD PM Softgel Capsules (Best THC-Free)

cbdmd pm capsules


Potency16.5-50 mg
Capsule Count30
Total cannabinoids500-1500 mg
Cost per mg $0.06-0.09
Third-Party TestsView report


  • Multi-ingredient sleep formula
  • Organic Colorado & Kentucky hemp source


  • Relatively low potency

If you’re looking for a THC-free option, cbdMD’s PM softgels are a great choice.

Each capsule contains 16.5 mg of broad-spectrum CBD, 3 mg of melatonin, and a blend of sleep-supporting herbs, including chamomile, valerian root, hops, lemon balm, and passionflower. There’s also a high-strength version with 40 mg CBD and 10 mg CBN.

CbdMD’s PM CBD oil with this same formula won the 2020 consumer-voted “Product of the Year” award for the best CBD sleep aid.

CbdMD is a popular brand known for its THC-free* formulations. All of its products are comprehensively tested by a third-party lab and sourced from organic Colorado and Kentucky hemp.

*THC-free is defined as below the level of detection using valid scientific analytical tools.

Green Roads Sleep CBD Capsules (Best Reviews)

green roads cbd melatonin capsules


Potency25 mg/ml
Capsule Count30
Total cannabinoids500-2000 mg
Cost per mg $0.03-0.04
Third-Party TestsView report

Use coupon code OFFER15 for 15% Off


  • Hundreds of satisfied customer reviews
  • Organic Colorado hemp source


  • Not a full-spectrum product

The sleep capsules from Green Roads have the best customer feedback of any CBD melatonin capsules, with over 500 satisfied reviews. They have a simple and straightforward formula made up of pure CBD and melatonin (5 mg).

Founded in 2013, Florida’s Green Roads is one of the biggest and most trusted CBD brands in the country. Its products are sourced from organic Colorado hemp and tested by a third-party lab for potency and contaminants.

How We Choose CBD Melatonin Capsules

All of the products we recommend are chosen based on several criteria, including:

  • Third-party testing: these tests prove that CBD products contain correct levels of CBD and are free of contaminants.
  • Formula: we looked for capsules that contain CBD and melatonin and other ingredients that can aid sleep.
  • Hemp source: high-quality CBD products are made from organic hemp plants grown in the United States or Europe.
  • Reputation: reputable companies have many positive reviews and a strong reputation in the CBD industry.
  • Potency: we don’t recommend products that contain too little CBD to give you an effect.

How to Use

CBD melatonin capsules should be taken about 30-60 minutes before bed to give them time to start working. Generally speaking, CBD capsules will start to work within 30 minutes on an empty stomach, but up to an hour or longer if you ate recently (3).

Did you know? We highly recommend taking capsules/softgels after or alongside fat-containing foods such as milk, peanut butter, eggs, or avocado. Research has shown that fats enhance the oral absorption of CBD by as much as 4 times (4).


CBD affects everyone differently, so there’s no one universal dose that will work for everyone. It depends on your body weight, the severity of your sleeping problems, the kind of product you’re using, and other factors.

If you’re new to CBD, we recommend the expert-backed “start low and go slow” approach (5).

You should begin with a small dose (5-15 mg) and pay attention to the effects over the next two hours. If you don’t notice anything (CBD has fairly subtle effects), you can try gradually increasing the dosage over time until you start to feel the desired effects.

For example, you might take one capsule the first night, and if there’s no noticeable difference, try two capsules the next night.

As a general rule of thumb, most people take 20-50 mg doses of CBD. However, keep in mind that your capsules also contain melatonin and potentially other active ingredients, so you may need to take less CBD than usual to get an effect.

Safety and Side Effects

CBD has been extensively researched, showing that it’s a safe compound (6). Even the World Health Organization (WHO) concluded in its 2018 report that CBD is “generally well tolerated with a good safety profile.” (7)

While CBD can cause side effects, they’re usually mild and include: (8)

  • Feeling tired or drowsy
  • Dry mouth
  • Diarrhea
  • Low blood pressure
  • Lightheadedness

CBD can also potentially increase or decrease the effects of some prescription drugs.

However, most of CBD’s side effects were reported by studies using large oral doses of CBD isolate. This means regular CBD users are unlikely to experience them.

Still, we recommend checking with your doctor before taking CBD, especially if you already take prescription drugs.

Melatonin Safety

Melatonin is also considered a generally safe supplement. Its most common side effects are similar to CBD: headaches, dizziness, nausea, and drowsiness. Other rare side effects include mild anxiety, short-lasting feelings of depression, and confusion.

Melatonin can also interact with some medications, such as anticonvulsants.

Again, it’s best to consult your doctor before taking a product containing melatonin and CBD, particularly if you’re taking prescription medications.

CBD & Melatonin FAQs


  1. Russo, Ethan B. “Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects.” British journal of pharmacology 163.7 (2011): 1344-1364.
  2. Pamplona, Fabricio A., Lorenzo Rolim da Silva, and Ana Carolina Coan. “Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis.” Frontiers in neurology 9 (2018): 759.
  3. Borodovsky, Jacob T., et al. “Smoking, vaping, eating: Is legalization impacting the way people use cannabis?.” International Journal of Drug Policy 36 (2016): 141-147.
  4. Birnbaum, Angela K., et al. “Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy.” Epilepsia 60.8 (2019): 1586-1592.
  5. Lucas, Catherine J., Peter Galettis, and Jennifer Schneider. “The pharmacokinetics and the pharmacodynamics of cannabinoids.” British journal of clinical pharmacology 84.11 (2018): 2477-2482.
  6. Bergamaschi, M. M., R. H. Queiroz, and A. W. Zuardi. “en Crippa, JA (2011). Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent.” Current Drug Safety 6.4: 237-249.
  7. WHO. Cannabidiol (CBD) Critical Review Report. June 7, 2018.
  8. Huestis, Marilyn A., et al. “Cannabidiol adverse effects and toxicity.” Current neuropharmacology 17.10 (2019): 974-989.
  9. Auld, Fiona, et al. “Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.” Sleep Medicine Reviews 34 (2017): 10-22.
  10. Costello, Rebecca B., et al. “The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature.” Nutrition journal 13.1 (2014): 1-17.
  11. Shannon, Scott, et al. “Cannabidiol in anxiety and sleep: a large case series.” The Permanente Journal 23 (2019).
  12. Capano, Alex, Richard Weaver, and Elisa Burkman. “Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study.” Postgraduate Medicine 132.1 (2020): 56-61.
  13. Babson, Kimberly A., James Sottile, and Danielle Morabito. “Cannabis, cannabinoids, and sleep: a review of the literature.” Current psychiatry reports 19.4 (2017): 1-12.

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