5 Best CBD Melatonin Capsules: Reviews & Guide (March 2021)

By | last updated August 28, 2021

Medically reviewed by
Saira Zulfiqar, PharmD

Evidence Based 16

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Many people take melatonin-infused CBD products to relieve insomnia and improve their overall sleep quality.

But with such a wide variety of available products, it’s not always easy to make a choice. Many products contain less CBD than advertised, while others are simply too weak to produce the desired effect.

To make your search easier, we compared dozens of CBD capsules based on third-party lab test results, hemp quality, potency, formula, customer reviews, price, and other criteria.

Read on for our reviews of the best CBD melatonin capsules.

CBD Terminology

  • Terpenes: aromatic plant compounds with a wide variety of beneficial properties (1).
  • Minor cannabinoids: CBN, CBG, and other beneficial cannabinoids that are present in smaller amounts than CBD.
  • Hemp: a non-intoxicating variety of cannabis with high CBD and low THC levels (>0.3%).
  • Full-spectrum: whole-plant hemp extract containing CBD, THC, and other beneficial hemp cannabinoids and terpenes. This CBD form is up to 4 times more potent than pure CBD (2).
  • Broad-spectrum: whole-plant hemp extract similar to full-spectrum CBD, but with THC removed (may contain trace amounts).
  • CBD isolate: pure CBD with all other hemp compounds removed.

Medterra Liposomal CBD + Melatonin (Best Overall)


  • Affordable
  • Organic Kentucky hemp source
  • Comprehensive third-party testing
  • U.S. Hemp Authority-certified


  • Not full-spectrum

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Out of all the products we reviewed, Medterra’s CBD + Melatonin capsules were the clear winner. They use a special liposomal formula to enhance the absorption of the active ingredients.

Each capsule has 25 mg of pure CBD alongside 3 mg of melatonin and a blend of natural ingredients that may help with sleep, including chamomile, passionflower, and GABA (3, 4, 5). There are 30 vegan capsules per bottle.

Medterra’s CBD+Melatonin capsules cost $0.07 per mg of CBD, which is fairly low for this kind of product. They’re comprehensively tested for potency and safety and sourced from organic Kentucky hemp.

California’s Medterra is one of the most reputable and affordable CBD brands. It’s certified by the U.S. Hemp Authority, a third-party program highlighting its commitment to high product quality standards.

CbdMD CBD PM Softgel Capsules (Best Formula)


  • Multi-ingredient sleep formula
  • Comprehensive third-party testing
  • Organic Colorado & Kentucky hemp source


  • Relatively low potency
  • Not full-spectrum

If you’re looking for the most effective sleep formula, cbdMD’s PM softgels are a great choice.

Each capsule contains 16.5 mg of broad-spectrum CBD, 3 mg of melatonin, and a blend of sleep-supporting herbs, including chamomile, valerian root, hops, lemon balm, and passionflower.

CbdMD’s PM CBD oil with this same formula won the 2020 consumer-voted “Product of the Year” award for the best CBD sleep aid.

You can choose between 30 or 60-capsule bottles with a price tag of $0.08-0.09 per mg of CBD, which is close to the price of regular CBD capsules.

CbdMD is a popular brand known for its THC-free* formulations. All of its products are comprehensively tested by a third-party lab and sourced from organic Colorado and Kentucky hemp.

*THC-free is defined as below the level of detection using valid scientific analytical tools.

Elixinol Good Night Capsules (Best Full-Spectrum)


  • Full-spectrum CBD
  • Comprehensive third-party testing
  • Organic Colorado hemp source


  • Relatively low potency

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Full-spectrum hemp extract is considered the best form of CBD because it contains the full range of beneficial cannabinoids and other active compounds from the plant.

Elixinol’s Good Night capsules are one of the only full-spectrum CBD softgels on the market that have melatonin.

These vegan-friendly capsules hold 15 mg of CBD and 2 mg of melatonin and come in packs of 10 or 60. They cost $0.08-0.07 per mg of CBD, which is a below-average cost for melatonin-infused CBD capsules.

According to third-party tests, they contain the minor cannabinoids CBDA and CBC, which confirms that you’re getting a proper full-spectrum product.

Elixinol is one of the oldest and most respected names in the CBD industry. The company is certified by the U.S. Hemp Authority, which means it follows hemp industry best practices. Its products are sourced from organic Colorado hemp.

Nanocraft CBD Softgel Capsules with Melatonin (Best with CBN)



  • Whole-plant formula
  • Organic Colorado hemp source
  • Comprehensive third-party testing
  • Added CBN


  • Not full-spectrum

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Although many people prefer to combine CBD with melatonin, there’s one other helpful hemp ingredient to look for — cannabinol (CBN).

This minor cannabinoid is increasingly being added to sleep-focused CBD products because it’s believed to have sedative effects.

Nanocraft’s night capsules provide 25 mg of broad-spectrum CBD alongside 2.5 mg of CBN and 1 mg of melatonin, with 30 capsules per bottle. Third-party tests verify that they contain CBD, CBN, and several other minor cannabinoids.

They cost $0.10 per mg of CBD/CBN, which is slightly more than most melatonin CBD capsules but is still a solid price.

California’s Nanocraft is a fitness-oriented CBD brand founded in 2016. Its products are sourced from organic Colorado hemp and go through extensive third-party testing.

Green Roads Sleep CBD Capsules (Best Value)


  • Affordable
  • Organic Colorado hemp source
  • Comprehensive third-party testing


  • Not a full-spectrum product

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If you’re looking to get the best bang for your buck, we recommend Green Roads.

The company’s sleep capsules have a simple and effective formula made up of pure CBD (25 mg) and melatonin (5 mg), for a total of 30 capsules with 750 mg of CBD.

They cost less than $0.07 per mg of CBD, which is one of the lowest prices you’ll find for melatonin-infused CBD capsules.

Founded in 2013, Florida’s Green Roads is one of the biggest and most trusted CBD brands in the country. Its products are sourced from organic Colorado hemp and tested by a third-party lab for potency and contaminants.

How We Choose CBD Melatonin Capsules

All of the products we recommend are chosen based on several criteria, including:

  • Third-party testing: these tests prove that CBD products contain correct levels of CBD and are free of contaminants.
  • Formula: we looked for capsules that contain CBD and melatonin and other ingredients that can aid sleep.
  • Hemp source: high-quality CBD products are made from organic hemp plants grown in the United States or Europe.
  • Reputation: reputable companies have many positive reviews and a strong reputation in the CBD industry.
  • Potency: we don’t recommend products that contain too little CBD to give you an effect.

How to Use

CBD melatonin capsules should be taken about 30-60 minutes before bed to give them time to start working. Generally speaking, CBD capsules will start to work within 30 minutes on an empty stomach, but up to an hour or longer if you ate recently (6).

Did you know? If your capsules contain powder, we highly recommend taking them alongside fat-containing foods, such as milk, cheese, eggs, or avocado. Research has shown that fats improve the oral bioavailability (fancy word for absorption) of CBD (7). You don’t need to do this if you’re using CBD softgels because they already contain fats.


CBD affects everyone differently, so there’s no one universal dose that will work for everyone. It depends on your body weight, the severity of your sleeping problems, the kind of product you’re using, and other factors.

If you’re new to CBD, we recommend the expert-backed “start low and go slow” approach (8).

You should begin with a small dose (5-15 mg) and pay attention to the effects over the next two hours. If you don’t notice anything (CBD has fairly subtle effects), you can try gradually increasing the dosage over time until you start to feel the desired effects.

For example, you might take one capsule the first night, and if there’s no noticeable difference, try two capsules the next night.

As a general rule of thumb, most people take 20-50 mg doses of CBD. However, keep in mind that your capsules also contain melatonin and potentially other active ingredients, so you may need to take less CBD than usual to get an effect.

Safety and Side Effects

CBD has been extensively researched, showing that it’s a safe compound (9). Even the World Health Organization (WHO) concluded in its 2018 report that CBD is “generally well tolerated with a good safety profile.” (10)

While CBD can cause side effects, they’re usually mild and include: (11)

  • Feeling tired or drowsy
  • Dry mouth
  • Diarrhea
  • Low blood pressure
  • Lightheadedness

CBD can also potentially increase or decrease the effects of some prescription drugs.

However, most of CBD’s side effects were reported by studies using large oral doses of CBD isolate. This means regular CBD users are unlikely to experience them.

Still, we recommend checking with your doctor before taking CBD, especially if you already take prescription drugs.

Melatonin Safety

Melatonin is also considered a generally safe supplement. Its most common side effects are similar to CBD: headaches, dizziness, nausea, and drowsiness. Other rare side effects include mild anxiety, short-lasting feelings of depression, and confusion.

Melatonin can also interact with some medications, such as anticonvulsants.

Again, it’s best to consult your doctor before taking a product containing melatonin and CBD, particularly if you’re taking prescription medications.

CBD and Melatonin FAQs

Why Combine CBD with Melatonin?

If you’re looking to improve your sleep, combining CBD with melatonin is a no-brainer. Melatonin is arguably the most researched sleep aid out there, with strong evidence that it can help with insomnia, jet lag-related sleep problems, other sleep disorders, and support overall sleep quality (12, 13).

Does CBD Help with Sleep?

Although more research is needed, multiple studies have shown that CBD can support a healthy sleep cycle by reducing issues that lead to poor sleep quality, such as anxiety and pain (14, 15). Additionally, high doses of CBD (over 100 mg) can potentially make you sleepy directly, by working as a sedative (16).


  1. Russo, Ethan B. “Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects.” British journal of pharmacology 163.7 (2011): 1344-1364.
  2. Pamplona, Fabricio A., Lorenzo Rolim da Silva, and Ana Carolina Coan. “Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis.” Frontiers in neurology 9 (2018): 759.
  3. Adib-Hajbaghery, Mohsen, and Seyedeh Nesa Mousavi. “The effects of chamomile extract on sleep quality among elderly people: A clinical trial.” Complementary therapies in medicine 35 (2017): 109-114.
  4. Guerrero, Fructuoso Ayala, and Graciela Mexicano Medina. “Effect of a medicinal plant (Passiflora incarnata L) on sleep.” Sleep Science 10.3 (2017): 96.
  5. Hepsomali, Piril, et al. “Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: A systematic review.” Frontiers in Neuroscience 14 (2020).
  6. Borodovsky, Jacob T., et al. “Smoking, vaping, eating: Is legalization impacting the way people use cannabis?.” International Journal of Drug Policy 36 (2016): 141-147.
  7. Birnbaum, Angela K., et al. “Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy.” Epilepsia 60.8 (2019): 1586-1592.
  8. Lucas, Catherine J., Peter Galettis, and Jennifer Schneider. “The pharmacokinetics and the pharmacodynamics of cannabinoids.” British journal of clinical pharmacology 84.11 (2018): 2477-2482.
  9. Bergamaschi, M. M., R. H. Queiroz, and A. W. Zuardi. “en Crippa, JA (2011). Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent.” Current Drug Safety 6.4: 237-249.
  10. WHO. Cannabidiol (CBD) Critical Review Report. June 7, 2018.
  11. Huestis, Marilyn A., et al. “Cannabidiol adverse effects and toxicity.” Current neuropharmacology 17.10 (2019): 974-989.
  12. Auld, Fiona, et al. “Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders.” Sleep Medicine Reviews 34 (2017): 10-22.
  13. Costello, Rebecca B., et al. “The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature.” Nutrition journal 13.1 (2014): 1-17.
  14. Shannon, Scott, et al. “Cannabidiol in anxiety and sleep: a large case series.” The Permanente Journal 23 (2019).
  15. Capano, Alex, Richard Weaver, and Elisa Burkman. “Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study.” Postgraduate Medicine 132.1 (2020): 56-61.
  16. Babson, Kimberly A., James Sottile, and Danielle Morabito. “Cannabis, cannabinoids, and sleep: a review of the literature.” Current psychiatry reports 19.4 (2017): 1-12.

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