Best CBD Creams & Topicals for Eczema: Reviews & Guide (2021)

By | last updated August 15, 2021

Medically reviewed by
Saira Zulfiqar, PharmD

Evidence Based 22

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There’s growing evidence that CBD’s anti-inflammatory, antioxidant, and other beneficial properties can help with eczema. 

But with so many CBD topicals on the market, it can be difficult to choose the right one, especially with a reasonable price.

That’s why we compared dozens of topical products based on their formula, third-party lab test results, hemp quality, potency, customer reviews, price, and more.

Here are the best CBD creams and other topical CBD products for eczema.

CBD Terminology

  • Terpenes: aromatic plant compounds with a wide variety of beneficial properties (1).
  • Minor cannabinoids: CBN, CBG, and other beneficial cannabinoids found in smaller amounts than CBD. For hemp, THC can also count as a minor cannabinoid.
  • Hemp: non-intoxicating cannabis variety with high CBD and low THC levels (less than 0.3%).
  • Full-spectrum: whole-plant hemp extract containing multiple cannabinoids, terpenes, and flavonoids. This form of CBD is about 4 times more potent than pure CBD (2).
  • Broad-spectrum: whole-plant hemp extract similar to full-spectrum CBD, but with THC removed (may contain trace amounts).
  • CBD isolate: pure CBD with all other hemp compounds removed.

CBDefine Skin Care Cream (Best Overall)


  • Full-spectrum CBD
  • Added ingredients that can help with eczema
  • Affordable price
  • Organic Colorado hemp source
  • Comprehensive third-party testing
  • U.S. Hemp Authority-certified


  • One potency option

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The overall best CBD cream for eczema is offered by CBDistillery. This popular, reputable Colorado brand offers a full range of high-quality CBD products at affordable prices.

The company’s CBDefine cream comes in a 30 ml jar providing 500 mg of full-spectrum CBD. It’s formulated with all-natural skincare ingredients, such as tea tree oil and hemp seed oil. These ingredients can help with conditions like eczema.

Like all CBDistillery products, this cream is sourced from organic Colorado hemp and tested by a third-party lab to verify its potency and safety. 

The CBDefine skincare cream costs $0.10 per milligram (mg) of CBD, which is lower than the average price for CBD creams.

CBDistillery is also one of few brands with U.S. Hemp Authority Certification, which means it follows hemp industry best practices.

Lazarus Naturals CBD Lotion (Best Lotion and Value)


  • Excellent price
  • Full-spectrum CBD
  • Three scent and size options
  • Extensive third-party testing
  • High-quality organic Oregon hemp source


  • Fewer additional ingredients that can help with eczema

Our top recommendation to get the best bang for your buck is Lazarus Naturals. This ethical brand provides some of the lowest prices for high-quality CBD products.

This is the best CBD lotion for eczema and it costs only $0.04 per mg of CBD. Such low prices for a high-quality CBD topical are unheard of.

Lazarus’ lotion contains full-spectrum CBD extract alongside other compounds that can relieve inflammation and provide other benefits, such as aloe vera leaf juice and jojoba seed oil.

It comes in three sizes, 300 mg (1 oz), 1000 mg (3.3 oz), or 2000 mg (6.7 oz) of CBD, as well as three scents: unscented, Pacific pine, and Portland rose.

Lazarus Naturals also offers a full-spectrum balm with the same per-mg price containing 400 or 1200 mg of CBD. It contains similar ingredients but with a higher CBD potency (20 mg/ml). 

Lazarus Naturals is one of the most respected and experienced CBD brands. It’s an employee-owned company that grows most of its hemp in Central Oregon and provides extensive third-party lab test results for all products.

In comparison, most CBD companies buy their hemp or finished extracts from other producers.

Endoca CBD Cream (Best Quality)


  • Full-spectrum CBD
  • Added ingredients that can help with eczema
  • High-quality organic Danish hemp source
  • Extensive third-party and in-house testing
  • Affordable price


  • Some may prefer American-made products

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If quality is your top concern, then the CBD cream from Endoca is a great option. Denmark’s Endoca is one of the most experienced, reputable CBD brands in the world.

This product is another serious contender for the best CBD cream for eczema.

It comes in a 100 ml jar containing either 450 mg or 1500 mg of full-spectrum CBD. The ingredients list includes shea butter, vitamin E, coconut oil, and other natural substances that can help with eczema by moisturizing the skin and reducing itching.

Endoca’s cream costs €0.04 per mg of CBD. As far as topical CBD products go, this affordable price is considered well below average.

Unlike most CBD companies, Endoca controls the entire process from seed to shelf and tests at every step — growing, harvesting, extracting, and the finished product. 

The company grows its organic hemp in Denmark in partnership with local farmers and has its products tested by a third-party lab.

CBDfx Calming CBD Balm Stick (Best Salve)


  • Added ingredients that can help with eczema
  • Excellent price
  • Organic Kentucky hemp source
  • Extensive third-party testing


  • Not a full-spectrum product

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Balms and salves are a great choice for people who prefer simple, water-free topical products. One of the best CBD salves for eczema is offered by CBDfx.

This popular California-based brand is known for its expertly formulated CBD products ranging from tinctures to vape e-liquids. Its calming balm is specifically designed to soothe sensitive skin without being irritating. 

Each 60 ml stick contains 750 mg or 3000 mg of pure CBD isolate blended with all-natural skincare ingredients that can moisturize, reduce inflammation, and help with other eczema symptoms, including tea tree oil, lavender, and chamomile.

Derived from organic Kentucky hemp, this balm is comprehensively tested by a third-party lab to confirm that it’s safe and potent. CBDfx’s calming balm has a per-mg price of $0.03-0.05, which is incredibly low.

Kiara Naturals CBD Blue Magic Cream (Best Formula)



  • Anti-eczema herbal formula
  • High potency
  • Swiss hemp source
  • Third-party testing


  • Not a full-spectrum product
  • Lacks third-party contaminant tests

If you’re looking for a formula that’s specifically designed for eczema and related inflammatory skin concerns, we recommend the blue magic cream from Kiara Naturals.

It carries 1000 mg of pure CBD and CBG in a 30 ml container, giving it a high potency of 33 mg/ml.

More importantly, it contains seven botanical ingredients that can help with eczema, inflammation, and skin repair: aloe vera, gotu kola, indigofera, Chinese goldthread, Chinese skullcap, stellaria, and vitamin E.

This third-party tested cream costs $0.09 per mg of CBD, which is quite good since you’re getting so many added ingredients.

Kiara Naturals is a Swiss brand known for offering CBD products infused with popular medicinal herbs.

CBDMEDIC Eczema Ointment (Best Specialized Topical)


  • Anti-eczema formula
  • Whole-plant hemp extract
  • Organic American hemp source
  • Third-party tested


  • Low potency

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The eczema medicated ointment from CBDMEDIC is one of the only CBD topicals designed specifically for eczema. It contains 1% colloidal oatmeal, a popular natural ingredient that can help reduce itching, dryness, and other symptoms of eczema.

Aside from that, the ingredients list includes 200 mg of broad-spectrum CBD and other compounds that may be helpful for eczema, including tea tree oil, jojoba seed oil, zinc, and beeswax.

This third-party tested, 40-gram ointment is derived from organic hemp cultivated in Colorado and Oregon. With a cost of $0.15 per mg of CBD, this product is close to average price point for CBD topicals. However, you’re still getting a good deal because of its unique formulation.

CBDMEDIC is owned by Charlotte’s Web, one of the oldest and most respected CBD brands in the world.

PlusCBD Gold Formula CBD Balm (Best Travel-Size)


  • Full-spectrum CBD
  • Added ingredients that can help with eczema
  • Organic European hemp source
  • Comprehensive in-house and third-party testing
  • U.S. Hemp Authority-certified


  • Relatively expensive

The travel-size hemp balm from PlusCBD oil is a great choice if you’re looking for a product you can take with you and use on the go. 

It comes in a 0.42 oz stick with 45 mg of full-spectrum CBD alongside multiple ingredients that may be beneficial for inflammation, itching, and dryness, including sweet almond oil, white willow bark, and tocopherol (vitamin E).

It’s sourced from organic European hemp and costs $0.33 per mg of CBD. This price is higher than average for CBD topicals, but still reasonable given PlusCBD’s premium-level product quality. 

PlusCBD was one of the first American CBD companies and continues to be popular today. It tests all of its products in-house and through a third-party lab. 

PlusCBD is also unique for being one of the only CBD brands to hold both self-affirmed Generally Recognized as Safe (GRAS) status and U.S. Hemp Authority Certification, two rigorous safety and quality compliance programs.

How We Choose CBD Creams & Topicals

Here are the criteria we use to find the right CBD creams and topicals for eczema:

  • Third-party test results (to verify the CBD content and lack of contaminants)
  • Formula (we look for added ingredients that can help with eczema)
  • Type of CBD (to get the best effects)
  • Product potency (to avoid products with too little CBD)
  • Hemp quality (to get a high-quality product)
  • Company reputation (to verify the company can be trusted)
  • Price (to get a good deal)

Read on for a closer look at how we judge these factors. You can also use these tips to find the best CBD creams on your own.

Third-Party Testing

Third-party testing is the best way to confirm the efficacy and safety of CBD products. These tests are done by an independent laboratory that checks whether a given product carries as much CBD as it says on the label. 

Third-party tests can also look for the presence of pesticides, heavy metals, and other contaminants.

In this day and age, all reputable CBD companies utilize third-party testing and share the test results publicly on their websites. A lack of these tests is a big red flag. 

We check the test results for all the products we review to make sure they contain advertised levels of CBD, the correct type of CBD, and are free of contaminants. For full-spectrum products, we also check the concentrations of minor cannabinoids (and terpenes, if available).


We look for topical products that contain additional natural ingredients that can help with eczema, such as tea tree oil. Read more below about what kinds of ingredients you want to look for.

Hemp Quality

CBD comes from hemp, which means the plant quality and cultivation process used matters. The best American hemp is organic and grown in one of three states: Colorado, Kentucky, and Oregon. 

European countries are also an excellent source of hemp because many have been growing it continuously for centuries. 

Check the brand’s website for this information. It’s even better if the company uses USDA-certified organic ingredients or directly grows its hemp.

Type of CBD

As we highlighted at the beginning of the article, there are three main types of CBD: isolate, full-spectrum, and broad-spectrum. 

If you want to get the best effects out of a CBD product for eczema or any other health issues, it’s best to use a full-spectrum or broad-spectrum product. 

That’s because they benefit from the cannabis “entourage effect” — the combined effects of all cannabis compounds working together in synergy instead of pure CBD on its lonesome (1). 

Company Reputation

We also consider the reputation of CBD companies. The brands we recommend have overwhelmingly positive customer reviews that help verify that you’re getting effective CBD oil and good customer service.

They’re also transparent about their hemp source, third-party testing results, the people behind the company, and provide other helpful details to build trust with customers.


CBD oil is not cheap, so we also consider the price. We look for products that are affordable yet of good quality. We also make it easy to tell if you’re paying a low, average, or high price by comparing the price per milligram (mg) of CBD. 

Generally speaking, topical CBD products fall into three tiers:

  1. Low: $0.10 or less per mg
  2. Average: $0.11-$0.25 per mg
  3. High: $0.26+ per mg

CBD Dosage for Eczema

There isn’t enough evidence to recommend a specific dose of CBD that’s ideal for eczema. Besides, the ideal dose varies from person to person based on the severity of your symptoms, the type of product you’re using, and other factors.

The best thing you can do is look for a product that has a potency of at least 4 mg of CBD per ml to make sure that it’s strong enough to have an effect on your skin. Anything less than that runs the risk of being too weak to provide a benefit. 

Safety and Side Effects

CBD is already a safe, non-intoxicating substance that’s only been associated with few and minor side effects (3).

Additionally, topical products infused with CBD are even safer because cannabidiol has a hard time penetrating into your skin and reaching the bloodstream. Since CBD can’t reach the blood, that means it can’t even cause any side effects.

Nonetheless, you should be aware that your skin can react negatively to other ingredients in a topical CBD product. 

Guide to Using CBD for Eczema

Interested in trying out CBD for eczema but not sure where to start? Here’s our evidence-based buying guide to using CBD for this common skin condition.

What is CBD?

Cannabidiol (CBD) is a natural cannabinoid compound that comes from cannabis. Thanks to its non-intoxicating properties and multiple health benefits, CBD has grown widely popular in the past several years.

CBD is typically sourced from hemp, which is a type of cannabis with high cannabidiol but low THC levels (0.3% or less).

Most people use it in the form of CBD oil, a liquid tincture where the CBD is dissolved in a carrier oil to aid its absorption and applied under the tongue. However, CBD can also be used in many other products, including topicals such as creams, salves, lotions, and balms.

What is Eczema?

Also known as atopic dermatitis, eczema is a condition characterized by red, itchy, and inflamed skin. Eczema tends to last a long time and with ongoing flare-ups. It’s estimated to affect 20% of children and up to 10% of adults in high-income countries (4).

Health experts believe this condition is linked to immune system dysfunction & allergies, stress, as well as other factors that can disrupt the skin’s barrier, which protects you from external threats and seals in moisture. 

Eczema is not curable, and therapy usually focuses on soothing and preventing the flare-ups. 

CBD Benefits for Eczema

CBD may help relieve the inflammation that characterizes eczema, which in turn can alleviate symptoms such as itching, redness, and dryness.

One promising Italian study tested the effects of a CBD-infused ointment on people with psoriasis, eczema, and scarring related to these conditions. 

The study participants used the ointment daily for 90 days, experiencing an improvement of skin hydration, elasticity, and other measures of skin health, as well as reduced scarring and blemishes (5).

CBD can also help eczema sufferers indirectly through its beneficial effects on mood, anxiety, and sleep. Research suggests that these issues are more common in people suffering from eczema and may worsen its symptoms (6, 7, 8, 9).

Did you know? Adding hemp seed oil to your diet — the oil pressed out of hemp seeds, not the same thing as CBD oil — may also help with eczema. In one study, people who used dietary hemp seed oil saw improvements in eczema symptoms, whereas those who were taking olive oil had no improvement (10). 

How Does CBD Help with Eczema?

Researchers believe CBD can have a positive effect on eczema by interacting with the body’s endocannabinoid system (ECS). 

This system is composed of three parts: cannabinoid receptors, endocannabinoids (cannabinoids that your body makes), and special enzymes that build and break them down.

The major role of the ECS is to maintain homeostasis, a healthy state of balance throughout the whole body. As part of its job, the ECS plays an important role in the health of your skin by controlling inflammation, cell growth, and other crucial processes (11).

Researchers theorize that ECS dysfunction could even be at the core of many health disorders, including eczema (12).

CBD can support the ECS by suppressing the enzyme that breaks down anandamide, one of the main endocannabinoids made in the body (13). 

Anandamide has been demonstrated to reduce skin inflammation and itching, highlighting the involvement of the ECS in healthy skin function (14).

Also, test-tube studies have shown that CBD can help regulate the dysfunctional immune system responses that may play a role in eczema (15). This isn’t surprising as the ECS is also known to regulate immune system function (16).

Other Helpful Topical Ingredients for Eczema

If you want to use a CBD-infused topical product for eczema, it’s helpful to look for one that contains some of the following ingredients:

  • Vitamin E: also known as tocopherol, this vitamin has been demonstrated to improve itching, eczema extent, and other measures of eczema severity in research studies (17).
  • Colloidal oatmeal: a review of multiple studies found that products containing colloidal oatmeal improved itching, dryness, eczema severity, and overall quality of life in eczema sufferers (18).
  • Emollients/moisturizers: Moisturizing the skin is one of the best approaches to eczema because it helps protect the damaged skin barrier and keep in moisture. Some studies have shown that emollients are beneficial for eczema (19).

Other natural ingredients listed below may also be beneficial for some people with eczema. However, their effects are more variable and don’t have as much research evidence:

  • Tea tree oil: there are some anecdotal reports of tea tree oil helping with eczema, although it doesn’t seem to work for everyone. One study found that tea tree oil improved contact dermatitis and had potential as an “anti-eczematic agent” (20).
  • Coconut oil: some people with eczema swear by the benefits of coconut oil, while others find that it only makes things worse. In any case, there’s evidence that coconut oil can reduce skin inflammation and enhance barrier function, both of which are beneficial for eczema (21).
  • Aloe vera: this popular plant is proposed to have antibacterial, wound healing, and immunity-modulating properties (22). However, there’s a lack of evidence for its benefits specifically in eczema.

How To Apply CBD Topicals for Eczema

You can apply a topical CBD product directly to the area of skin affected by eczema. It’s best to clean and dry the area first and then massage the product into your skin as you would with most regular topicals.

You can start with a small amount and see if that provides you with some relief. If that’s not enough, you can always apply more later.

Can Topical CBD Cause a Failed Drug Test for THC?

It’s highly unlikely that a topical CBD product will show up as a positive drug test for THC. Not only do CBD products contain very small THC amounts (less than 0.3%) but topically applied CBD has a hard time reaching the bloodstream. 

Can You Apply CBD Oil to Eczema?

Yes, you can apply standard CBD oil to eczema. Having said that, you’ll probably have better results from using a dedicated topical product since CBD oil tinctures are designed to be taken sublingually (under the tongue).

Topicals vs. Other CBD Products

Topical CBD products differ from CBD oil, capsules, and edibles in several important ways. For one, they’re applied to the skin instead of taken orally. Furthermore, their effects are only felt where you apply them, instead of the whole body. 

One advantage of topical products is that the CBD is unlikely to absorb deep enough to reach the bloodstream, which reduces your chances of side effects. The effects of topical CBD last for at least a few hours.


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  2. Pamplona, Fabricio A., Lorenzo Rolim da Silva, and Ana Carolina Coan. “Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis.” Frontiers in neurology 9 (2018): 759.
  4. Laughter, M. R., et al. “The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017.” British Journal of Dermatology 184.2 (2021): 304-309.
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  6. Sales, Amanda J., et al. “Cannabidiol induces rapid and sustained antidepressant-like effects through increased BDNF signaling and synaptogenesis in the prefrontal cortex.” Molecular neurobiology 56.2 (2019): 1070-1081.
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